CKIε/δ-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock

A striking feature of the circadian clock is its flexible yet robust response to various environmental conditions. To analyze the biochemical processes underlying this flexible-yet-robust characteristic, we examined the effects of 1,260 pharmacologically active compounds in mouse and human clock cel...

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Autori principali: Isojima, Yasushi, Nakajima, Masato, Ukai, Hideki, Fujishima, Hiroshi, Yamada, Rikuhiro G., Masumoto, Koh-hei, Kiuchi, Reiko, Ishida, Mayumi, Ukai-Tadenuma, Maki, Minami, Yoichi, Kito, Ryotaku, Nakao, Kazuki, Kishimoto, Wataru, Yoo, Seung-Hee, Shimomura, Kazuhiro, Takao, Toshifumi, Takano, Atsuko, Kojima, Toshio, Nagai, Katsuya, Sakaki, Yoshiyuki, Takahashi, Joseph S., Ueda, Hiroki R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736905/
https://ncbi.nlm.nih.gov/pubmed/19805222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908733106
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