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Balance between DBT/CKIε kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein

The first circadian-relevant kinase to be identified was DOUBLE-TIME (DBT) in Drosophila, a homolog of vertebrate CKIε, which regulates the progressive phosphorylation and stability of PERIOD (PER) proteins in animals. A negative feedback loop wherein PER directly inhibits the transcriptional activi...

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Autores principales: Kim, Eun Young, Edery, Isaac
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458851/
https://ncbi.nlm.nih.gov/pubmed/16603629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511215103
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