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Long-term effects of losartan on structure and function of the thoracic aorta in a mouse model of Marfan syndrome

BACKGROUND AND PURPOSE: During development of thoracic aortic aneurysms in a mouse model of Marfan syndrome, upregulation of matrix metalloproteinase (MMP)-2 and -9 was accompanied by compromised aortic constriction and endothelium-dependent relaxation. Losartan has been proposed for the prevention...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yang, HH Clarice, Kim, Jong Moo, Chum, Elliott, van Breemen, Cornelis, Chung, Ada WY
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795217/
https://ncbi.nlm.nih.gov/pubmed/19814725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00443.x
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