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Imbalanced synthesis of cyclooxygenase-derived thromboxane A(2) and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome
BACKGROUND AND PURPOSE: Thoracic aortic dissection is a life-threatening complication of Marfan syndrome, a connective tissue disorder caused by mutations in the gene encoding fibrillin-1. We have demonstrated that nitric oxide-mediated endothelial-dependent relaxation is impaired in the thoracic ao...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2042958/ https://ncbi.nlm.nih.gov/pubmed/17641673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707391 |
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