Endothelial dysfunction and compromised eNOS/Akt signaling in the thoracic aorta during the progression of Marfan syndrome

BACKGROUND AND PURPOSE: Aortic complications account for the major mortality in Marfan syndrome (MFS), a connective tissue disorder caused by mutations in FBN1 encoding fibrillin-1. We hypothesized that MFS impaired endothelial function and nitric oxide (NO) production in the aorta. EXPERIMENTAL APP...

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Detalhes bibliográficos
Main Authors: Chung, A W Y, Au Yeung, K, Cortes, S F, Sandor, G G S, Judge, D P, Dietz, H C, van Breemen, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2013910/
https://ncbi.nlm.nih.gov/pubmed/17339838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707181
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