Transforming growth factor-β-stimulated clone-22 (TSC-22) is an androgen regulated gene that enhances apoptosis in prostate cancer following IGF-IR inhibition

PURPOSE: Inhibition of IGF signaling using the human IGF-IR monoclonal antibody A12 is most effective at inducing apoptosis in prostate cancer xenografts in the presence of androgen. We undertook this study to determine mechanisms for increased apoptosis by A12 in the presence of androgens. EXPERIME...

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Hauptverfasser: Sprenger, Cynthia C. T., Haugk, Kathleen, Sun, Shihua, Coleman, Ilsa, Nelson, Peter S., Vessella, Robert L., Ludwig, Dale L., Wu, Jennifer D., Plymate, Stephen R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795132/
https://ncbi.nlm.nih.gov/pubmed/19996218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0264
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