Response of the Insulin-Like Growth Factor (IGF) System to IGF-IR Inhibition and Androgen Deprivation in a Neoadjuvant Prostate Cancer Trial: Effects of Obesity and Androgen Deprivation

CONTEXT: Prostate cancer patients at increased risk for relapse after prostatectomy were treated in a neoadjuvant study with androgen deprivation therapy (ADT) in combination with cixutumumab, an inhibitory fully human monoclonal antibody against IGF receptor 1 (IGF-IR). OBJECTIVE: A clinical trial...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Dean, James P., Sprenger, Cynthia C., Wan, Junxiang, Haugk, Kathleen, Ellis, William J., Lin, Daniel W., Corman, John M., Dalkin, Bruce L., Mostaghel, Elahe, Nelson, Peter S., Cohen, Pinchas, Montgomery, Bruce, Plymate, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2013
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4430583/
https://ncbi.nlm.nih.gov/pubmed/23533230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-3856
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