Neoadjuvant-intensive androgen deprivation therapy selects for prostate tumor foci with diverse subclonal oncogenic alterations

Primary prostate cancer (PCa) can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant PCa (mCRPC) remains unclear. In this study, we microdissected residual PCa foci in radical prostatectomies from 18 men treated with neoadjuvant intensiv...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Sowalsky, Adam G., Ye, Huihui, Bhasin, Manoj, Van Allen, Eliezer M., Loda, Massimo, Lis, Rosina T., Montaser-Kouhsari, Laleh, Calagua, Carla, Ma, Fen, Russo, Joshua W., Schaefer, Rachel J., Voznesensky, Olga S., Zhang, Zhenwei, Bubley, Glenn J., Montgomery, Bruce, Mostaghel, Elahe A., Nelson, Peter S., Taplin, Mary-Ellen, Balk, Steven P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095796/
https://ncbi.nlm.nih.gov/pubmed/29921690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0610
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