Neoadjuvant-intensive androgen deprivation therapy selects for prostate tumor foci with diverse subclonal oncogenic alterations

Primary prostate cancer (PCa) can have extensive microheterogeneity, but its contribution to the later emergence of metastatic castration-resistant PCa (mCRPC) remains unclear. In this study, we microdissected residual PCa foci in radical prostatectomies from 18 men treated with neoadjuvant intensiv...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Sowalsky, Adam G., Ye, Huihui, Bhasin, Manoj, Van Allen, Eliezer M., Loda, Massimo, Lis, Rosina T., Montaser-Kouhsari, Laleh, Calagua, Carla, Ma, Fen, Russo, Joshua W., Schaefer, Rachel J., Voznesensky, Olga S., Zhang, Zhenwei, Bubley, Glenn J., Montgomery, Bruce, Mostaghel, Elahe A., Nelson, Peter S., Taplin, Mary-Ellen, Balk, Steven P.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095796/
https://ncbi.nlm.nih.gov/pubmed/29921690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-0610
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