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Converting an injectable protein therapeutic into an oral form:phenylalanine ammonia lyase for phenylketonuria
Phenylalanine ammonia lyase (PAL) has long been recognized as a potential enzyme replacement therapeutic for treatment of Phenylketonuria. However, various strategies for the oral delivery of PAL have been complicated by the low intestinal pH, aggressive proteolytic digestion and circulation time in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2795033/ https://ncbi.nlm.nih.gov/pubmed/19793667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.09.002 |
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