Formulation and PEGylation optimization of the therapeutic PEGylated phenylalanine ammonia lyase for the treatment of phenylketonuria

Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is not currently an option. Treatment of PKU with an alt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Bell, Sean M., Wendt, Dan J., Zhang, Yanhong, Taylor, Timothy W., Long, Shinong, Tsuruda, Laurie, Zhao, Bin, Laipis, Phillip, Fitzpatrick, Paul A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345807/
https://ncbi.nlm.nih.gov/pubmed/28282402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173269
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