STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THE THERAPEUTIC A. VARIABILIS PHENYLALANINE AMMONIA LYASE

We have recently observed promising success in a mouse model at treating the metabolic disorder phenylketonuria (PKU) with phenylalanine ammonia lyase (PAL) from R. toruloides and A. variabilis. Both molecules, however, required further optimization in order to overcome problems with protease suscep...

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Bibliografiset tiedot
Päätekijät: Wang, Lin, Gamez, Alejandra, Archer, Holly, Abola, Enrique E., Sarkissian, Christineh N., Fitzpatrick, Paul, Wendt, Dan, Zhang, Yanhong, Vellard, Michael, Bliesath, Joshua, Bell, Sean, Lemont, Jeff, Scriver, Charles R., Stevens, Raymond C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556551/
https://ncbi.nlm.nih.gov/pubmed/18556022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.025
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