Converting an injectable protein therapeutic into an oral form:phenylalanine ammonia lyase for phenylketonuria

Phenylalanine ammonia lyase (PAL) has long been recognized as a potential enzyme replacement therapeutic for treatment of Phenylketonuria. However, various strategies for the oral delivery of PAL have been complicated by the low intestinal pH, aggressive proteolytic digestion and circulation time in...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Kang, Tse Siang, Wang, Lin, Sarkissian, Christineh N., Gámez, Alejandra, Scriver, Charles R., Stevens, Raymond C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795033/
https://ncbi.nlm.nih.gov/pubmed/19793667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2009.09.002
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы