Alternative Mechanism of Activation of the Epithelial Na(+) Channel by Cleavage

We examined activation of the human epithelial sodium channel (ENaC) by cleavage. We focused on cleavage of αENaC using the serine protease subtilisin. Trimeric channels formed with αFM, a construct with point mutations in both furin cleavage sites (R178A/R204A), exhibited marked reduction in sponta...

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Bibliographic Details
Main Authors: Hu, John Cong, Bengrine, Abderrahmane, Lis, Agnieszka, Awayda, Mouhamed S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794749/
https://ncbi.nlm.nih.gov/pubmed/19858199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032870
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