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Alternative Mechanism of Activation of the Epithelial Na(+) Channel by Cleavage
We examined activation of the human epithelial sodium channel (ENaC) by cleavage. We focused on cleavage of αENaC using the serine protease subtilisin. Trimeric channels formed with αFM, a construct with point mutations in both furin cleavage sites (R178A/R204A), exhibited marked reduction in sponta...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794749/ https://ncbi.nlm.nih.gov/pubmed/19858199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032870 |
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