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Mutant N143P Reveals How Na(+) Activates Thrombin
The molecular mechanism of thrombin activation by Na(+) remains elusive. Its kinetic formulation requires extension of the classical Botts-Morales theory for the action of a modifier on an enzyme to correctly account for the contribution of the E*, E, and E:Na(+) forms. The extended scheme establish...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794733/ https://ncbi.nlm.nih.gov/pubmed/19846563 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069500 |
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