CCL2 Is a Negative Regulator of AMP-Activated Protein Kinase to Sustain mTOR Complex-1 Activation, Survivin Expression, and Cell Survival in Human Prostate Cancer PC3 Cells

CCL2 is a cytokine prevalent in the prostate cancer tumor microenvironment. Recently, we reported that CCL2 induces the mammalian target of rapamycin (mTOR) pathway to promote prostate cancer PC3 cell survival; however, the mechanism used by CCL2 to maintain mTOR complex-1 (mTORC1) activation requir...

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Hlavní autoři: Roca, Hernan, Varsos, Zachary S, Pienta, Kenneth J
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794512/
https://ncbi.nlm.nih.gov/pubmed/20019839
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