Stabilization of G-quadruplex in the BCL2 promoter region in double-stranded DNA by invading short PNAs

Numerous regulatory genes have G-rich regions that can potentially form quadruplex structures, possibly playing a role in transcription regulation. We studied a G-rich sequence in the BCL2 gene 176-bp upstream of the P1 promoter for G-quadruplex formation. Using circular dichroism (CD), thermal dena...

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Main Authors: Onyshchenko, Mykola I., Gaynutdinov, Timur I., Englund, Ethan A., Appella, Daniel H., Neumann, Ronald D., Panyutin, Igor G.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2009
Teme:
Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794188/
https://ncbi.nlm.nih.gov/pubmed/19820116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp840
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