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PPG Peptide Nucleic Acids that Promote DNA Guanine Quadruplexes

Properly designed peptide nucleic acids (PNAs) can invade G-rich DNA duplexes and induce the formation of a G-quadruplex in the free DNA strand. Replaceing guanines in the PNA sequence with PPG nucleobases eliminates G-quadruplex formation with PNA and promotes invasion of the target DNA.

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Detalhes bibliográficos
Main Authors:	Englund, Ethan A., Gupta, Pankaj, Micklitsch, Christopher M., Onyshchenko, Mykola I., Remeeva, Evgenia, Neumann, Ronald D., Panyutin, Igor G., Appella, Daniel H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	2014
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4180717/ https://ncbi.nlm.nih.gov/pubmed/25044379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201402224
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PPG Peptide Nucleic Acids that Promote DNA Guanine Quadruplexes

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