Sonic Hedgehog Induces Notch Target Gene Expression in Vascular Smooth Muscle Cells via VEGF-A

OBJECTIVE: Notch, VEGF and components of the Hedgehog (Hh) signaling pathway have been implicated in vascular morphogenesis. The role of Notch in mediating hedgehog control of adult vascular smooth muscle (SMC) growth and survival remains unexplored. METHODS AND RESULTS: In cultured SMC, activation...

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Detalhes bibliográficos
Main Authors: Morrow, David, Cullen, John P., Liu, Weimin, Guha, Shaunta, Sweeney, Catherine, Birney, Yvonne A., Collins, Nora, Walls, Dermot, Redmond, Eileen M., Cahill, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794048/
https://ncbi.nlm.nih.gov/pubmed/19407245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.186890
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