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Multiple Protonation States of Vesicular Acetylcholine Transporter Detected by Binding of [(3)H]Vesamicol
Vesicular acetylcholine transporter (VAChT) is inhibited by (−)-vesamicol [(−)-trans-2-(4-phenylpiperidino)cyclohexanol], which binds tightly to an allosteric site. The tertiary alkylamine center in (−)-vesamicol is protonated and positively charged at acidic and neutral pH and unprotonated and unch...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793091/ https://ncbi.nlm.nih.gov/pubmed/19685929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900759v |
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