Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion

AIMS: Although in vitro studies indicate that oxazepam is an isoform-selective substrate probe for UDP-glucuronosyltransferase 2B15, the utility of this drug as an in vivo probe is uncertain. The main aim of this study was to determine whether common missense polymorphisms in the UGT2B15 gene (D85Y...

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Bibliografiske detaljer
Main Authors: He, Xi, Hesse, Leah M, Hazarika, Suwagmani, Masse, Gina, Harmatz, Jerold S, Greenblatt, David J, Court, Michael H
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2009
Fag:
Pharmacogenetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791978/
https://ncbi.nlm.nih.gov/pubmed/19916996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03519.x
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