Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells

BACKGROUND: The phosphatidylinositol-3-kinase/Akt pathway has been described to be critical in the survival of chronic lymphocytic leukemia cells. In this study we analyzed the effect of two selective chemical inhibitors of Akt (Akti-1/2 and A-443654) on the survival of chronic lymphocytic leukemia...

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Bibliografske podrobnosti
Main Authors: de Frias, Mercè, Iglesias-Serret, Daniel, Cosialls, Ana M., Coll-Mulet, Llorenç, Santidrián, Antonio F., González-Gironès, Diana M., de la Banda, Esmeralda, Pons, Gabriel, Gil, Joan
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2009
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791940/
https://ncbi.nlm.nih.gov/pubmed/19815839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.004028
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