Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

LKB1 encodes a serine/threonine kinase, which functions upstream of the AMP-activated protein kinase (AMPK) superfamily. To clarify the role of LKB1 in heart, we generated and characterized cardiac myocyte-specific LKB1 knock-out (KO) mice using α-myosin heavy chain-Cre deletor strain. LKB1-KO mice...

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Bibliographic Details
Main Authors: Ikeda, Yasumasa, Sato, Kaori, Pimentel, David R., Sam, Flora, Shaw, Reuben J., Dyck, Jason R. B., Walsh, Kenneth
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791013/
https://ncbi.nlm.nih.gov/pubmed/19828446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057273
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