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Crystal Structure and Functional Analysis of Homocitrate Synthase, an Essential Enzyme in Lysine Biosynthesis

Homocitrate synthase (HCS) catalyzes the first and committed step in lysine biosynthesis in many fungi and certain Archaea and is a potential target for antifungal drugs. Here we report the crystal structure of the HCS apoenzyme from Schizosaccharomyces pombe and two distinct structures of the enzym...

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Autors principals: Bulfer, Stacie L., Scott, Erin M., Couture, Jean-François, Pillus, Lorraine, Trievel, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791007/
https://ncbi.nlm.nih.gov/pubmed/19776021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.046821
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