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The Phosphatidylinositol 3-Kinase/Akt Pathway Regulates Transforming Growth Factor-β Signaling by Destabilizing Ski and Inducing Smad7

Ski is an oncoprotein that negatively regulates transforming growth factor (TGF)-β signaling. It acts as a transcriptional co-repressor by binding to TGF-β signaling molecules, Smads. Efficient TGF-β signaling is facilitated by rapid proteasome-mediated degradation of Ski by TGF-β. Here we report th...

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Detalhes bibliográficos
Main Authors: Band, Arja M., Björklund, Mia, Laiho, Marikki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790973/
https://ncbi.nlm.nih.gov/pubmed/19875456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.029488
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