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Differential regulation by ATP versus ADP further links CaMKII aggregation to ischemic conditions
CaMKII, a major mediator of synaptic plasticity, forms extra-synaptic clusters under ischemic conditions. This study further supports self-aggregation of CaMKII holoenzymes as the underlying mechanism. Aggregation in vitro was promoted by mimicking ischemic conditions: low pH (6.8 or less), Ca(2+) (...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790910/ https://ncbi.nlm.nih.gov/pubmed/19840793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.10.028 |
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