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Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers

INTRODUCTION: Women who carry mutations in BRCA1 and BRCA2 have a substantially increased risk of developing breast cancer as compared with the general population. However, risk estimates range from 20 to 80%, suggesting the presence of genetic and/or environmental risk modifiers. Based on extensive...

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Bibliografski detalji
Glavni autori: Neuhausen, Susan L, Brummel, Sean, Ding, Yuan Chun, Singer, Christian F, Pfeiler, Georg, Lynch, Henry T, Nathanson, Katherine L, Rebbeck, Timothy R, Garber, Judy E, Couch, Fergus, Weitzel, Jeffrey, Narod, Steven A, Ganz, Patricia A, Daly, Mary B, Godwin, Andrew K, Isaacs, Claudine, Olopade, Olufunmilayo I, Tomlinson, Gail, Rubinstein, Wendy S, Tung, Nadine, Blum, Joanne L, Gillen, Daniel L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790858/
https://ncbi.nlm.nih.gov/pubmed/19843326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2414
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