Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

Human tyrosyl–DNA phosphodiesterase (TDP1) hydrolyzes the phosphodiester bond at a DNA 3′ end linked to a tyrosyl moiety. This type of linkage is found at stalled topoisomerase I (Top1)–DNA covalent complexes, and TDP1 has been implicated in the repair of such complexes. Here we show that Top1-assoc...

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Autors principals: Das, Benu Brata, Antony, Smitha, Gupta, Shalu, Dexheimer, Thomas S, Redon, Christophe E, Garfield, Susan, Shiloh, Yosef, Pommier, Yves
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790489/
https://ncbi.nlm.nih.gov/pubmed/19851285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.302
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