Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

Macrophages exhibit endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological significance and the underlying mechanisms remain unknown. Here, we demonstrate that mitigation of ER stress with a chemical chaperone results in m...

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Autores principales: Erbay, Ebru, Babaev, Vladimir R., Mayers, Jared R., Makowski, Liza, Charles, Khanichi N., Snitow, Melinda, Fazio, Sergio, Wiest, Michelle M., Watkins, Steven M., Linton, MacRae F., Hotamisligil, Gökhan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790330/
https://ncbi.nlm.nih.gov/pubmed/19966778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2067
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