DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway

DLC1, a tumor suppressor gene that encodes a RhoGTPase-activating protein, is recurrently downregulated or silenced in various solid tumors and hematological malignancies due to epigenetic modifications or genomic deletion. Here, we identified DLC-1 promoter hypermethylation in 43 out of 44 multiple...

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Bibliografiske detaljer
Main Authors: Ullmannova-Benson, Veronika, Guan, Ming, Zhou, Xiaoling, Tripathi, Veenu, Yang, Xu-Yu, Zimonjic, Drazen B., Popescu, Nicholas C
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790147/
https://ncbi.nlm.nih.gov/pubmed/18923442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2008.285
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