DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis

The process of cell dissemination from the primary tumors to distant sites is the most harmful event during cancer progression, and the leading cause of cancer death. We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human...

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Dettagli Bibliografici
Pubblicato in:Int J Oncol
Autori principali: ZHOU, XIAOLING, ZIMONJIC, DRAZEN B., PARK, SANG-WON, YANG, XU-YU, DURKIN, MARIAN E., POPESCU, NICHOLAS C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7185305/
https://ncbi.nlm.nih.gov/pubmed/18497990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo_32_6_1285
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