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RNA Adenosine Deaminase ADAR1 Deficiency Leads to Increased Activation of Protein Kinase PKR and Reduced Vesicular Stomatitis Virus Growth Following Interferon Treatment

Two size forms of ADAR1 adenosine deaminase are known, one constitutively expressed (p110) and the other interferon (IFN)-induced (p150). To test the role of ADAR1 in viral infection, HeLa cells with ADAR1 stably knocked down and 293 cells over expressing ADAR1 were utilized. Over expression of p150...

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Bibliografiske detaljer
Main Authors: Li, Zhiqun, Wolff, Karen C., Samuel, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789878/
https://ncbi.nlm.nih.gov/pubmed/19913273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.10.026
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