Binding Ensemble PROfiling with (F)photoaffinity Labeling (BEProFL) Approach: Mapping the Binding Poses of HDAC8 Inhibitors

A Binding Ensemble PROfiling with (F)photoaffinity Labeling (BEProFL) approach that utilizes photolabeling of HDAC8 with a probe containing a UV-activated aromatic azide, mapping the covalent modifications by liquid chromatography-tandem mass-spectrometry, and a computational method to characterize...

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Bibliografiske detaljer
Main Authors: He, Bai, Velaparthi, Subash, Pieffet, Gilles, Pennington, Chris, Mahesh, Aruna, Holzle, Denise L., Brunsteiner, Michael, van Breemen, Richard, Blond, Sylvie Y., Petukhov, Pavel A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789734/
https://ncbi.nlm.nih.gov/pubmed/19886628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9005077
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