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Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases

A concise synthesis of (14)C labeled meropenem prepared from (14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies.

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Detalles Bibliográficos
Autores principales: Kastrinsky, David B., Barry, Clifton E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789577/
https://ncbi.nlm.nih.gov/pubmed/20161438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2009.10.124
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