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CD4(+) T Cell Development in a Mouse Expressing a Transgenic TCR Derived from a Regulatory T Cell

CD4(+)Foxp3(+) regulatory T cells (Tregs) maintain peripheral tolerance and influence immune responses to foreign antigens. The thymus is an important source of Tregs, but controversy exists as to whether T cells are selected into the Treg lineage based on signals received through TCRs specific for...

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Bibliografiske detaljer
Main Authors: DiPaolo, Richard J., Shevach, Ethan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789337/
https://ncbi.nlm.nih.gov/pubmed/19065648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838772
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