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Collapsing SNP Genotypes in Case-Control Genome-Wide Association Studies Increases the Type I Error Rate and Power
Genome-wide association studies are now widely used tools to identify genes and/or regions which may contribute to the development of various diseases. With case-control data a 2×3 contingency table can be constructed for each SNP to perform genotype-based tests of association. An increasingly commo...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2789285/ https://ncbi.nlm.nih.gov/pubmed/18673292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2202/1544-6115.1325 |
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