Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality

During graft-versus-host disease (GVHD), donor T cells become activated and migrate to tissue sites. Previously, we demonstrated a crucial role for the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) in GVHD regulation. Here, we show that upon arrival in the colon, activated donor T cells...

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Main Authors: Jasperson, Lisa K., Bucher, Christoph, Panoskaltsis-Mortari, Angela, Mellor, Andrew L., Munn, David H., Blazar, Bruce R.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Transplantation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788979/
https://ncbi.nlm.nih.gov/pubmed/19828695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-227587
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