Heterodimerization of the Sialidase NEU1 with the Chaperone Protective Protein/Cathepsin A Prevents Its Premature Oligomerization

Lysosomal neuraminidase-1 (NEU1) forms a multienzyme complex with β-galactosidase and protective protein/cathepsin A (PPCA). Because of its association with PPCA, which acts as a molecular chaperone, NEU1 is transported to the lysosomal compartment, catalytically activated, and stabilized. However,...

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Bibliographic Details
Main Authors: Bonten, Erik J., Campos, Yvan, Zaitsev, Viateslav, Nourse, Amanda, Waddell, Brett, Lewis, William, Taylor, Garry, d'Azzo, Alessandra
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788892/
https://ncbi.nlm.nih.gov/pubmed/19666471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031419
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