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Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor
Protective protein/cathepsin A (PPCA) has a serine carboxypeptidase activity of unknown physiological function. We now demonstrate that this protease activity triggers the degradation of the lysosome-associated membrane protein type 2a (lamp2a), a receptor for chaperone-mediated autophagy (CMA). Deg...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Oxford University Press
2003
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC140041/ https://ncbi.nlm.nih.gov/pubmed/12505983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg002 |
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