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Protective Protein/Cathepsin A Rescues N-glycosylation defects in Neuraminidase-1
BACKGROUND: Neuraminidase-1 (NEU1) catabolizes the hydrolysis of sialic acids from sialo-glycoconjugates. NEU1 depends on its interaction with the protective protein/cathepsin A (PPCA) for lysosomal compartmentalization and catalytic activation. Murine NEU1 contains 4 N-glycosylation sites, 3 of whi...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2888680/ https://ncbi.nlm.nih.gov/pubmed/19714866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2009.01.006 |
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