Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases

Activation of the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway is one the most frequent genetic events in human cancer. A cell-based imaging assay that monitored the translocation of the Akt effector protein, Forkhead box O (FOXO), from the cytoplasm to the nucleus was employed to screen a...

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Bibliografische gegevens
Hoofdauteurs: Link, Wolfgang, Oyarzabal, Julen, Serelde, Beatriz G., Albarran, Maria Isabel, Rabal, Obdulia, Cebriá, Antonio, Alfonso, Patricia, Fominaya, Jesus, Renner, Oliver, Peregrina, Sandra, Soilán, David, Ceballos, Plácido A., Hernández, Ana-Isabel, Lorenzo, Milagros, Pevarello, Paolo, Granda, Teresa G., Kurz, Guido, Carnero, Amancio, Bischoff, James R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2009
Onderwerpen:
Mechanisms of Signal Transduction
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788888/
https://ncbi.nlm.nih.gov/pubmed/19690175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.038984
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