Fragment-Hopping-Based Discovery of a Novel Chemical Series of Proto-Oncogene PIM-1 Kinase Inhibitors

A new chemical series, triazolo[4,5-b]pyridines, has been identified as an inhibitor of PIM-1 by a chemotype hopping strategy based on a chemically feasible fragment database. In this case, structure-based virtual screening and in silico chemogenomics provide added value to the previously reported s...

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Detalhes bibliográficos
Main Authors: Saluste, Gustavo, Albarran, Maria I., Alvarez, Rosa M., Rabal, Obdulia, Ortega, Miguel Angel, Blanco, Carmen, Kurz, Guido, Salgado, Antonio, Pevarello, Paolo, Bischoff, James R., Pastor, Joaquin, Oyarzabal, Julen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480357/
https://ncbi.nlm.nih.gov/pubmed/23115625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045964
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