Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA

Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electrophoretic mobility gel shift assay (EMSA) and filter binding assay. Of 179 chemicals scree...

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Detalhes bibliográficos
Main Authors: Chae, Min-Ju, Sung, Hye Youn, Kim, Eun-Hye, Lee, Mira, Kwak, Hojoong, Chae, Chong Hak, Kim, Sunwoo, Park, Woong-Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society of Medical Biochemistry and Molecular Biology 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788736/
https://ncbi.nlm.nih.gov/pubmed/19949288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2009.41.11.088
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