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Modifications at the C-Terminus to Improve Pyrrole-Imidazole Polyamide Activity in Cell Culture

Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA-minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture. Gene regulation by polyamides requires efficient cellular uptake and nuclear localization properties for candidat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Jacobs, Claire S., Dervan, Peter B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788682/
https://ncbi.nlm.nih.gov/pubmed/19572551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900256f
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