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Modifications at the C-Terminus to Improve Pyrrole-Imidazole Polyamide Activity in Cell Culture
Pyrrole-imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA-minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture. Gene regulation by polyamides requires efficient cellular uptake and nuclear localization properties for candidat...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788682/ https://ncbi.nlm.nih.gov/pubmed/19572551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900256f |
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