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Probes for Narcotic Receptor Mediated Phenomena. 39.1 Enantiomeric N-Substituted Benzofuro[2,3-c]pyridin-6-ols: Synthesis and Topological Relationship to Oxide-bridged Phenylmorphans2

Enantiomers of N-substituted benzofuro[2,3-c]pyridin-6-ols have been synthesized and the subnanomolar affinity and potent agonist activity of the known racemic N-phenethyl substituted benzofuro[2,3-c]pyridin-6-ol can now be ascribed to the 4aS,9aR enantiomer. The energy minimized structures suggest...

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Библиографические подробности
Главные авторы: Zhang, Yi, Lee, Yong Sok, Rothman, Richard B., Dersch, Christina M., Deschamps, Jeffrey R., Jacobson, Arthur E., Rice, Kenner C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788676/
https://ncbi.nlm.nih.gov/pubmed/19627147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9004225
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