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Reduced Digestive Vacuolar Accumulation of Chloroquine is Not Linked to Resistance to Chloroquine Toxicity
Chloroquine (CQ) accumulation studies in live malaria parasites are typically done at low nM [CQ], and definition of CQ resistance (CQR) has been via growth inhibition assays vs low dose CQ (i.e. via IC(50) ratios). These data have led to the near universally accepted idea that reduced parasite CQ a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788207/ https://ncbi.nlm.nih.gov/pubmed/19883122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901765v |
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