Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

Amyloid-β (Aβ) has been identified as a key component in Alzheimer's disease (AD). Significant in vitro and human pathological data suggest that intraneuronal accumulation of Aβ peptides plays an early role in the neurodegenerative cascade. We hypothesized that targeting an antibody-based thera...

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Detalhes bibliográficos
Main Authors: Sudol, Kelly L, Mastrangelo, Michael A, Narrow, Wade C, Frazer, Maria E, Levites, Yona R, Golde, Todd E, Federoff, Howard J, Bowers, William J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788047/
https://ncbi.nlm.nih.gov/pubmed/19638957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.174
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