Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

Amyloid-β (Aβ) has been identified as a key component in Alzheimer's disease (AD). Significant in vitro and human pathological data suggest that intraneuronal accumulation of Aβ peptides plays an early role in the neurodegenerative cascade. We hypothesized that targeting an antibody-based thera...

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Bibliographische Detailangaben
Hauptverfasser: Sudol, Kelly L, Mastrangelo, Michael A, Narrow, Wade C, Frazer, Maria E, Levites, Yona R, Golde, Todd E, Federoff, Howard J, Bowers, William J
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2009
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788047/
https://ncbi.nlm.nih.gov/pubmed/19638957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.174
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