Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

Amyloid-β (Aβ) has been identified as a key component in Alzheimer's disease (AD). Significant in vitro and human pathological data suggest that intraneuronal accumulation of Aβ peptides plays an early role in the neurodegenerative cascade. We hypothesized that targeting an antibody-based thera...

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מידע ביבליוגרפי
Main Authors: Sudol, Kelly L, Mastrangelo, Michael A, Narrow, Wade C, Frazer, Maria E, Levites, Yona R, Golde, Todd E, Federoff, Howard J, Bowers, William J
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2009
נושאים:
Original Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788047/
https://ncbi.nlm.nih.gov/pubmed/19638957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.174
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