Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

Several human monoclonal antibodies (hmAbs) including b12, 2G12, and 2F5 exhibit relatively potent and broad HIV-1-neutralizing activity. However, their elicitation in vivo by vaccine immunogens based on the HIV-1 envelope glycoprotein (Env) has not been successful. We have hypothesized that HIV-1 h...

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Autores principales: Xiao, Xiaodong, Chen, Weizao, Feng, Yang, Zhu, Zhongyu, Prabakaran, Ponraj, Wang, Yanping, Zhang, Mei-Yun, Longo, Nancy S., Dimitrov, Dimiter S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787893/
https://ncbi.nlm.nih.gov/pubmed/19748484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.09.029
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